LP
Highest purity Selank we've sourced
This lot had 99.1% purity per our LC-MS verification. Batch traceable to the COA provided. Will be our go-to source for all cognitive peptide research going forward.
HPLC Verified
>98% Purity
COA Included
AXON Cognitive & Nootropic
Dihexa
$169.17
Dihexa is a small-molecule angiotensin IV analogue and AT4/IRAP inhibitor. Studied for synaptogenic activity and cognitive enhancement, it is reported to be approximately 10 million times more potent than BDNF in facilitating new synapse formation.
| Format | Lyophilized Vial |
|---|---|
| Dosage | 5mg |
| Purity | >98% |
| Sub-Line | AXON |
Also available: Dihexa Capsules (10mg) →
In Stock — Overnight and 2–3 day delivery available
Product Information
Dihexa | Angiotensin IV Analogue — Research Grade
Dihexa (PNB-0408) is a brain-penetrant small molecule derived from angiotensin IV with high affinity for the AT4 receptor (IRAP, insulin-regulated aminopeptidase). It was developed at Washington State University and has been characterised as an exceptionally potent synaptogenic compound in preclinical models.
Mechanism of Action
- AT4/IRAP inhibition — binds and inhibits IRAP, increasing local concentration of endogenous neuropeptides including oxytocin and vasopressin at synaptic sites
- HGF/c-Met signalling — activates hepatocyte growth factor receptor (c-Met) in hippocampal neurons, a pathway critical for synaptogenesis
- Synapse formation — preclinical data report synaptogenic potency approximately 10 million-fold greater than BDNF in hippocampal neuron models
- BBB penetration — lipophilic structure allows oral bioavailability and CNS access in rodent models
Research Areas
Dihexa is studied in Alzheimer disease models, cognitive decline, traumatic brain injury, and synaptogenesis research. Its extreme potency in preclinical synaptogenesis assays makes it a high-interest compound in neuroplasticity research.
For Research Use Only. Rainbow Peptide supplies Dihexa exclusively for in vitro and laboratory research purposes. Not for human or veterinary use.
Frequently Asked Questions
- What is Dihexa?
- Dihexa is a small-molecule angiotensin IV analogue and AT4/IRAP inhibitor. Studied for synaptogenic activity and cognitive enhancement, it is reported to be approximately 10 million times more potent than BDNF in facilitating new synapse formation.
- Is Dihexa for sale at Rainbow Peptide?
- Yes. Dihexa is available for purchase with Certificate of Analysis confirming >98% HPLC purity. Every order Overnight and 2–3 day delivery available. For Research Use Only.
- What purity is your Dihexa?
- Rainbow Peptide's Dihexa is >98% pure, HPLC verified by an accredited third-party laboratory. A COA is included with every order.
- Is Dihexa safe for human use?
- No. Dihexa is strictly For Research Use Only (RUO). It is not intended for human consumption and is not intended to diagnose, treat, cure, or prevent any disease.
- How quickly does Dihexa ship?
- Overnight and 2–3 day delivery available. Ships in temperature-controlled packaging.
Third-Party Verified
Every Order Ships with a Certificate of Analysis
We don't just claim purity — we prove it. Every batch of Dihexa is independently tested by an accredited third-party laboratory before it reaches you. Your COA is linked to your specific lot number.
- HPLC purity analysis — minimum threshold >98%
- Mass spectrometry — molecular weight confirmation
- Lot number traceable to your order
- Endotoxin limits verified — safe for cell-based assays
RAINBOW PEPTIDE LABS CERTIFICATE OF ANALYSIS
Product Dihexa
Lot # RP-00040-A
HPLC Purity >98.0% >98.5% PASS
Mass Spec (MW) Confirmed Confirmed PASS
Endotoxin <1 EU/mg <0.5 EU/mg PASS
Visual Inspection White powder White powder PASS
What Researchers Say
Verified purchases from active research labs and scientists
5.00
★★★★★
2 verified reviews JA
Consistent quality for cognitive research
Semax lot tested above spec. Excellent solubility, expected in vitro behavior. The detailed COA makes this compliant with our supplier verification protocol.
PW
Good purity, great documentation
Mass spec and HPLC data attached to COA. Our internal QC confirmed results. Packaging was excellent — arrived at correct temperature with cold pack still active.
