RH
Exceptional purity for peptide research
We've been sourcing research-grade peptides for several years. Rainbow Peptide's vials consistently pass our HPLC verification — purity exceeds 98% every batch. COA matched our internal testing exactly.
HPLC Verified
>98% Purity
COA Included
SOMA Recovery & Tissue Repair
Larazotide (20mg)
$249.99
Larazotide (AT-1001) tight junction regulatory peptide, 20mg per vial. Studied for intestinal permeability, zonulin pathway inhibition, and celiac disease models. COA included.
| Format | Lyophilized Vial |
|---|---|
| Dosage | 20mg per vial |
| Purity | >98% |
In Stock — Overnight and 2–3 day delivery available
Product Information
Larazotide | Tight Junction Regulator — Gut Permeability Research
Larazotide (AT-1001) is an 8-amino acid synthetic peptide that acts as an antagonist of the zonulin pathway — the primary physiological regulator of intestinal tight junctions. Zonulin (haptoglobin-2) activates PAR2 receptors to open tight junctions via the PKCα/ZONAB pathway. Larazotide competitively blocks this signaling to maintain or restore intestinal barrier integrity. It has completed Phase IIb clinical trials for celiac disease.
Mechanism of Action
- Zonulin pathway antagonism — blocks PAR2 receptor activation by haptoglobin-2 (zonulin), preventing tight junction disassembly
- Tight junction stabilisation — preserves occludin, claudin-1/2, and ZO-1 at cell-cell junctions under inflammatory challenge
- Epithelial resistance restoration — increases transepithelial electrical resistance (TEER) in intestinal cell monolayer models
- Cytokine modulation — reduces intestinal TNF-α and IL-6 associated with barrier disruption
Research Areas
Larazotide is studied in celiac disease, intestinal permeability, inflammatory bowel disease, food allergy mechanisms, and "leaky gut" research models. Works synergistically with KPV (MC1R anti-inflammatory) and BPC-157 (GI mucosal protection) in comprehensive GI barrier research panels.
For Research Use Only. Rainbow Peptide supplies this compound exclusively for in vitro and laboratory research purposes. Not for human or veterinary use.
Frequently Asked Questions
- What is Larazotide (20mg)?
- Larazotide (AT-1001) tight junction regulatory peptide, 20mg per vial. Studied for intestinal permeability, zonulin pathway inhibition, and celiac disease models. COA included.
- Is Larazotide (20mg) for sale at Rainbow Peptide?
- Yes. Larazotide (20mg) is available for purchase with Certificate of Analysis confirming >98% HPLC purity. Every order Overnight and 2–3 day delivery available. For Research Use Only.
- What purity is your Larazotide (20mg)?
- Rainbow Peptide's Larazotide (20mg) is >98% pure, HPLC verified by an accredited third-party laboratory. A COA is included with every order.
- Is Larazotide (20mg) safe for human use?
- No. Larazotide (20mg) is strictly For Research Use Only (RUO). It is not intended for human consumption and is not intended to diagnose, treat, cure, or prevent any disease.
- How quickly does Larazotide (20mg) ship?
- Overnight and 2–3 day delivery available. Ships in temperature-controlled packaging.
Third-Party Verified
Every Order Ships with a Certificate of Analysis
We don't just claim purity — we prove it. Every batch of Larazotide (20mg) is independently tested by an accredited third-party laboratory before it reaches you. Your COA is linked to your specific lot number.
- HPLC purity analysis — minimum threshold >98%
- Mass spectrometry — molecular weight confirmation
- Lot number traceable to your order
- Endotoxin limits verified — safe for cell-based assays
RAINBOW PEPTIDE LABS CERTIFICATE OF ANALYSIS
Product Larazotide (20mg)
Lot # RP-00264-A
HPLC Purity >98.0% >98.5% PASS
Mass Spec (MW) Confirmed Confirmed PASS
Endotoxin <1 EU/mg <0.5 EU/mg PASS
Visual Inspection White powder White powder PASS
What Researchers Say
Verified purchases from active research labs and scientists
5.00
★★★★★
2 verified reviews MT
Reliable consistency batch to batch
Third order now. Consistent batch-to-batch results matter enormously in long-term research. Certificate of Analysis is detailed with mass spec data. Would not switch sources.
SK
Solid product, shipping was fast
Verified against our reference standards. Purity >98.2% by HPLC. Packaging was appropriate for temperature-sensitive peptides. Will re-order.
