SS-31 Capsules (20mg)

SS-31 Capsules | Elamipretide — Mitochondria-Targeted Research

SS-31 (Elamipretide; D-Arg-Dmt-Lys-Phe-NH₂) is a cell-permeable, mitochondria-targeted tetrapeptide that selectively accumulates at the inner mitochondrial membrane (IMM) where it binds cardiolipin — a unique phospholipid essential for cristae architecture and electron transport chain function. Phase II/III clinical trials have been conducted for heart failure, Barth syndrome, and Friedreich's ataxia. These capsules (20mg per capsule, 30 capsules) support oral delivery research protocols.

Mechanism of Action

• Cardiolipin binding — stabilises cardiolipin in the IMM, maintaining cytochrome c attachment and preventing its pro-apoptotic release
• ETC optimisation — improves electron flow through Complexes I, III, and IV, reducing electron leak and ROS production
• ATP synthesis restoration — restores ATP/ADP ratios in models of mitochondrial dysfunction and ischaemia
• Mitochondrial morphology — promotes fusion and reduces pathological fission in cardiomyocyte and neuron models

Research Areas

SS-31 capsules are studied in mitochondrial disease, cardiac failure models, ageing-associated mitochondrial decline, and neurodegenerative research. Commonly combined with MOTS-c and NAD+ in mitochondrial biology research panels.

For Research Use Only. Rainbow Peptide supplies this compound exclusively for in vitro and laboratory research purposes. Not for human or veterinary use.